Methyl B Complete This unique formula intends to support optimal methylation and help sustain healthy homocysteine levels already within normal range. These specific nutrients, when provided in activated forms, intend to support methylation and overall cardiovascular health. Methyl B Complete contains five key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic for increased bioactivity; Trimethylglycine (G); and vitamins B12, B6, and B2 (riboflavin). QUATREFOLIC VS FOLIC ACID Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the reduced and active form of folic acid so Quatrefolic completely bypasses the damaged MTHFR conversion step and delivers a finished folate the body can immediately use without any kind of metabolization. The other advantage is that Quatrefolic passes the gastric barrier and is absorbed mainly in the small intestine by a carrier mediated mechanism. The carrier is not saturated and this enables Quatrefolic to ensure a higher folate uptake. All Pure Therapeutics Formulas Meet or Exceed cGMP Quality Standards. This product is manufactured in the United States in a GMP certified facility.